Most skin treatments add something: volume, hydration or heat. PB Serum HA works the other way round. It uses enzymes to clear out damaged collagen and debris so that fresh tissue can form.
This page explains PB Serum HA facial rejuvenation treatment in Kuala Lumpur in plain terms. It covers how the enzymes work, the HA, Smooth and Drain versions, who it suits, the research, costs, results, risks and how it fits with skin boosters and lasers.
Not sure whether enzymes, a skin booster or a laser suits your skin?
To start, this short video from pbserum, the Spanish maker, shows the idea behind its enzyme range.
Source video: pbserum on YouTube
Face reshaping. Author: Dr. Eduardo Ortega (Peru).
Scars. Author: Dra. Maira González (Venezuela).
Clinical photos published by the brand, not BeauLife Clinic patients. Individual results vary.
Quick Answer: PB Serum HA is an injectable from Proteos Biotech in Madrid, Spain. It combines three recombinant enzymes, made by genetic engineering in bacteria, with hyaluronic acid. A doctor injects small amounts under the skin, where the enzymes break down tired collagen, small fat deposits and trapped fluid so the skin can renew itself.
The maker lists the three enzymes on its PB Serum HA range page:
PB Serum HA is one of several skin quality treatments at our aesthetic clinic in Kuala Lumpur. Because it removes rather than adds, it suits people who want a lighter, fresher face without extra fullness.
Quick Answer: PB Serum comes in several lines. The HA range holds all three enzymes in Low, Medium and High strengths; a 2026 facial study used the Low strength. Smooth+ holds only collagenase for texture. Drain+ holds only hyaluronidase for puffiness. The doctor picks or combines them for your skin and area.
| Product line | Enzymes inside | What doctors use it for |
|---|---|---|
| PB Serum HA (Low, Medium, High) | Collagenase PB220 + lipase PB500 + lyase PB72K, with hyaluronic acid | Laxity, jowls, double chin, fibrosis and scars; the Low strength was used on the face in the 2026 study |
| Smooth+ | Collagenase PB220 alone | Skin texture and evenness, without the fat-reducing enzyme |
| Drain+ | Hyaluronidase PB3000 alone | Puffiness and fluid; a more uniform look in set areas |
| Slim+ | Lipase PB500 alone | Body areas such as the abdomen and legs |
| Specific Face | Collagenase PB220 + lyase PB72K + keratinase PB333, with low-weight HA | Facial rejuvenation: skin texture and tone |
Details come from the maker’s Plus range and Specific range pages. Names differ by country; the HA range may appear as “HA 1.5” or “HA 2.0”. For the face, a gentle option keeps the cheeks’ natural fullness.
Quick Answer: Early evidence is encouraging but small. A 2026 study of five women found better skin texture and less laxity 45 days after one facial session, with new collagen seen on biopsy. A 2025 study of 29 patients found acne scars improved over four sessions. No large controlled trial has been published yet.
| What was studied | Main finding | Source |
|---|---|---|
| Face, 5 women aged 47–65 in Colombia: one session of PB Serum HA1.5 Low, then radiofrequency five days later | Better texture and less laxity in all five at 45 days; biopsies showed new collagen and elastic fibres. | Giraldo Mesa et al., 2026 |
| Acne scars, 29 patients: Specific Acne Scars with microneedling, four sessions over four months | Scar size, hydration and severity scores improved, most clearly after session four. | Batistella et al., 2025 |
| Cellulite on the legs, 4 women: PB Serum Medium, three sessions | All four improved, with no side effects reported. | Santaella-Sosa et al., 2024 |
| Filler overcorrection on the face, 5 patients: collagenase, hyaluronidase and lipase by cannula | All five improved after one session, including fat and silicone filler problems. | Castelanich et al., 2025 |
| Late swelling under the eyes after HA filler, 6 patients: hyaluronidase with collagenase PB220 | All six improved after one session, with no complications. | Castelanich et al., 2024 |
Sources: published studies via PubMed and AboutOpen. All were small case series without a control group; the first three include authors employed by the maker. Results vary.
The maker reports 86.9% to 94.7% patient satisfaction and no severe side effects in over 200 patients on its HA range page, but these are its own figures.
Quick Answer: PB Serum HA suits adults whose skin looks dull, dehydrated, uneven or slightly loose, especially with fine texture problems, mild jowls or puffiness. It is also used for some scars and areas of fibrosis. It is usually not the first choice for deep wrinkles, marked sagging or lost volume.
PB Serum HA facial rejuvenation treatment in Kuala Lumpur tends to suit people who:
It is usually not the right first step if your main concern is volume loss or deep folds. For marked jowls or fat under the chin, the doctor may also discuss an energy device such as Thermage.
Quick Answer: PB Serum HA facial rejuvenation treatment in Kuala Lumpur typically costs about RM 300 to 2,000 per session in the Klang Valley. The price depends on the product line, the strength, how many vials are used and the size of the area. Most plans need three to six sessions, so budget for the course.
| Treatment | Usual course | Market range (bar = upper end) | |
|---|---|---|---|
| PB Serum HA, per session | Usually 3–6 sessions | RM 300 – 2,000 | |
| Discovery PICO laser, per session | Usually 4–6 sessions | RM 600 – 2,000+ | |
| Rejuran, per session | Usually a 3-session course | RM 1,200 – 2,500 | |
| Profhilo, per 2 ml session | Usually a 2-session course | RM 2,000 – 4,500 | |
Market ranges compiled from publicly listed Klang Valley clinic prices, 2025–2026. Not BeauLife’s price list. Your exact quote is given after the consultation.
These are market ranges, not BeauLife’s price list. As an illustration, three sessions at the market range comes to about RM 900 to 6,000, and six sessions about RM 1,800 to 12,000. When comparing quotes, ask:
Want a clear plan and price for your skin?
Quick Answer: A PB Serum HA session takes about 45 minutes. After a skin check and cleansing, the doctor reconstitutes the vial and injects small amounts under the skin across the planned area, often in lines or with a fine cannula. Mild swelling, redness or bruising usually settles within a few days.
Some plans add microneedling or radiofrequency on a later day, as in the 2026 facial study; any add-on is costed first.
Quick Answer: Most PB Serum HA plans use three to six sessions, with the gap set by the doctor. Skin often feels softer within a week, while smoother, firmer-looking skin builds over two to four months as new collagen forms. Ageing continues, so maintenance sessions may be suggested.
| Time after first session | What usually happens |
|---|---|
| Day 0 | About 45 minutes in clinic. Tenderness and redness at the injection points. |
| Days 1–3 | Mild swelling peaks; some people bruise. Many return to work. |
| Days 4–7 | Swelling and bruising usually settle. Skin may already feel softer. |
| Weeks 1–6 | Further sessions, with the gap set by the doctor. |
| About 45 days | When the 2026 facial study saw better texture and new collagen. |
| Months 2–4 | The main window for smoother, firmer-looking skin after the full course. |
| Every few months | Optional maintenance, as natural ageing continues. |
Sources: Giraldo Mesa et al. (2026), Batistella et al. (2025) and the pbserum product range pages. Timings are typical ranges, not promises.
PB Serum HA often works as part of a plan. After the enzymes clear the way, a booster such as Profhilo in Kuala Lumpur can add hydration, and PICO laser for dark spots can treat pigment, on separate days.
Quick Answer: They solve different problems. PB Serum HA uses enzymes for texture, mild laxity and puffiness. Profhilo spreads a concentrated hyaluronic acid for hydration and early laxity. PICO laser targets dark spots and acne marks. Many plans use two of them in sequence rather than choosing just one.
| Feature | PB Serum HA | Profhilo | PICO laser |
|---|---|---|---|
| How it works | Enzymes break down tired collagen and fat and help fluid drain, so the skin rebuilds | Spreads a high-concentration HA to hydrate and support the skin | Laser energy breaks up pigment and prompts collagen |
| Main job | Texture, mild laxity, puffiness and fibrosis | Hydration and mild laxity | Dark spots, acne marks and tone |
| Usual course | 3–6 sessions | 2 sessions, 4 weeks apart | 4–6 sessions |
| Downtime | Mild swelling or bruising for a few days | Small bumps for a day or two | Redness for hours to a day |
| Typical Klang Valley market range | RM 300 – 2,000 per session | RM 2,000 – 4,500 per 2 ml | RM 600 – 2,000+ per session |
| Pairs well with | Skin boosters and lasers, on separate days | Lasers and collagen stimulators | Skin boosters and enzyme treatments |
Source: pbserum and IBSA product information, published studies, and publicly listed Klang Valley clinic prices, 2025–2026. Market ranges, not BeauLife’s price list.
For glow without injections, a genio facial treatment (the OxyGeneo facial) is gentler. For sensitive skin, Rejuran is often first; for acne scars, Sylfirm X RF microneedling.
Quick Answer: PB Serum HA is generally well tolerated in published reports, which describe no serious side effects. Common reactions are swelling, redness, tenderness and bruising for a few days. As with any injection, infection, lumps or an allergic reaction are possible, so it should be done by a trained doctor.
In Malaysia, look for the Medical Device Authority hologram security label on registered devices, and ask the doctor about the product’s registration status before treatment. Buying injectables online is unsafe.
Want to know if PB Serum HA suits your skin?
Quick Answer: BeauLife provides PB Serum HA facial rejuvenation treatment in Kuala Lumpur at an MOH-registered clinic (KKLIU 1970/2019) operating since 2017, where LCP-certified doctors perform every injectable treatment. The doctor explains whether enzymes, a booster or a laser fits your skin and gives the full price first, at five Klang Valley branches.
Branch addresses and maps are on our contact and branch locations page. You can also read more about BeauLife’s doctors and approach.
PB Serum HA makes sense if your skin looks dull, rough, puffy or slightly loose and you want improvement without added volume. Plan for three to six sessions of about 45 minutes, a few days of mild swelling or bruising, and gradual results over two to four months. The evidence is promising but small, so choose a doctor who explains the options, the risks and the full course price first.
It typically costs about RM 300 to 2,000 per session in the Klang Valley, depending on the product, the area and the dose. Most plans need three to six sessions. Your exact quote is given after a skin assessment.
No. It adds no volume. Its enzymes clear tired collagen, fat and fluid, while the hyaluronic acid hydrates.
Most plans use three to six sessions. The doctor sets the number and the gap between them based on your skin and the area treated.
Tell the doctor first, because some of these enzymes break down hyaluronic acid filler.
Book your PB Serum HA consultation
A BeauLife doctor will assess your skin, explain whether PB Serum HA or another option suits you and its risks, and give you a clear plan and price before anything starts.
