Botox & Body

Double Chin Fat Melting Injection: How It Works

TL;DR:

A double chin fat melting injection is often described as “dissolving” fat, which makes it sound gentle. In fact it is a controlled injury. The solution breaks open fat cells on contact, the area swells as the body reacts, and the swelling is part of how the treatment works. Knowing this in advance helps you plan the days after each session and judge the result at the right time.

This guide comes from BeauLife Clinic, an MOH-registered aesthetic clinic (KKLIU 1970/2019) operating since 2017, with LCP-certified doctors at five Klang Valley branches. It explains what is in the vial, where the needle goes and where it must not, what the trials found, and what a course costs. It does not replace an examination by a doctor.

First, a short training lecture for injectors on why the swelling after these injections is expected rather than a complication.

Kybella: Why Swelling Is the Treatment, Not a Problem

Source video: Empire Medical Training on YouTube

1. What is in a double chin fat melting injection?

Quick Answer: Most fat melting injections for the chin are based on deoxycholate (deoxycholic acid), a copy of a bile acid the body uses to digest fat. Kybella is the US-approved version for the chin. Aqualyx fat-dissolving injections, made in Italy, use a deoxycholate-based gel. A third family, phosphatidylcholine, is still being tested in trials.

Fat melting injections for the chin: ingredient, approval status and dosing
Comparison of Kybella, Aqualyx, MEI005 and AYP-101 by active ingredient, regulatory status and session protocol for submental fat.
ProductActive ingredientStatusHow it is dosed
Deoxycholate products
Kybella (ATX-101; Belkyra in Canada)Deoxycholic acid 10 mg/mLUS FDA-approved for fat under the chin only0.2 mL per point, 1 cm apart; up to 50 points (10 mL) per session; up to 6 sessions at least a month apart
AqualyxDeoxycholate-based gel, mixed with saline before useCE-marked in Europe since 2009; the maker now lists it as a cosmetic productTwo to three sessions, four to six weeks apart, per BeauLife’s protocol
MEI005Deoxycholic acid-based formulaPhase 3 trial in 325 Chinese adults; not yet approved there at publicationEvery 28 days, up to 6 sessions
Other families
AYP-101Soybean phosphatidylcholinePhase 2 trial in 96 Korean adults; investigationalEvery 2 weeks, up to 6 sessions

Sources: Kybella US prescribing information, 2015 (FDA); Marllor product page; Rauso & Salti 2015 (PMID 26319076); Ting et al. 2025 (PMID 40037621); Choi et al. 2025 (PMID 40850886); BeauLife Aqualyx treatment page. Compiled by BeauLife Clinic, November 2026.

The Kybella US prescribing information spells out the dose and grid in detail. Marllor, the maker of Aqualyx, describes it as a solution for localised fat and puts a QR code on each box so you can check it is genuine. Three points matter more than the brand name:

  • It works on contact. Deoxycholate damages any cell membrane it touches, so the depth of the needle decides both the result and the risk.
  • It is a local treatment. It reshapes one pocket of fat; it does not lower your weight.
  • Brands are not interchangeable. Kybella is not widely offered in Malaysia, so its trial results tell you how the ingredient behaves, not exactly what one Aqualyx session will do.
Key takeaway: The active ingredient is a bile-acid copy that breaks fat cells on contact. Ask which product, and how many millilitres, your doctor plans to use.

2. Who is a good candidate for chin fat injections?

Quick Answer: The ideal candidate has soft fat under the chin that can be pinched, is close to a stable weight and has reasonably firm skin. Injections do not tighten loose skin, reach fat beneath the neck muscle or fix a short chin bone. Our guide to chin fat removal treatment explains how to tell these causes apart.

SituationIs injection a fit?What a doctor may suggest
Small, soft, pinchable fullnessYesTwo to three sessions
Larger fullness that fills a cooling cupPossiblyCooltech Define fat freezing with no needles
Loose, crepey skin with little fatNoDENSITY skin tightening
Chin tip sits far behind the lower lipNoRestylane chin filler for projection
Pregnant, breastfeeding, infection in the area, trouble swallowingNot nowWait, or treat the medical issue first

Tell the doctor about blood thinners, a bleeding disorder, earlier neck surgery or any swallowing problem. The Kybella label warns that existing difficulty swallowing can get worse.

The same rule applies to every spot treatment: it shapes one area. That is also why calf injections in our Botox leg slimming guide are judged by outline, not by kilograms.

Key takeaway: Injections suit a small, soft pocket of fat in someone with a steady weight. Loose skin, deep fat and a weak chin need a different plan.

3. What happens during the injection session?

Quick Answer: A double chin fat melting injection session usually takes 30 to 45 minutes. The doctor confirms the fullness is fat, marks a grid, numbs or cools the skin, then places small amounts of solution into the fat layer. The doctor keeps away from a strip just below the jawline, where a nerve that moves the lower lip runs. Our Aqualyx page lists the aftercare.

  1. Assessment. The doctor checks your medical history and medicines, then pinches the area with your neck relaxed and tensed to confirm it is fat above the neck muscle.
  2. Product check. You can ask to see the sealed vial and scan the QR code on the box before anything is opened.
  3. Marking the safe zone. The doctor draws the treatment area and a grid of points about 1 cm apart, keeping a strip 1 to 1.5 cm below the jawbone clear.
  4. Comfort. Ice or a numbing cream or injection may be used, because the solution burns for a few minutes.
  5. Injection. Small amounts go into the fat layer at each point, staying out of the skin above and the muscle below.
  6. Aftercare. Cold packs, loose collars, no hard exercise or saunas for a day or two, and a review before the next session.

Why the strip below the jaw matters. The FDA label tells injectors not to inject above the lower border of the jawbone or within 1 to 1.5 cm below it. That is where the marginal mandibular nerve runs. A 2023 study of 62 patients treated inside this kind of mapped safe zone and reported no nerve weakness. A 2026 review of injection lipolysis concluded that safety depends mainly on anatomy, patient selection and technique.

Key takeaway: The session is short, but the map matters. Ask your doctor to show you the marked area and the line they will not cross.

Want to know if your chin suits injections?

A BeauLife doctor will pinch-test the area, show you the safe zone and explain how many sessions are likely. See how Aqualyx sessions are planned →

4. How well do fat melting injections work under the chin?

Quick Answer: In four placebo-controlled trials, about two-thirds of treated adults improved by at least one grade, against about one in five on placebo. That pattern held in North American trials and in a 2025 trial of 325 Chinese adults. Kybella was tested more than Aqualyx, so the Aqualyx treatment page notes its smaller studies separately.

Share of adults whose chin fat improved by at least one grade: treatment vs placebo
Grouped bars comparing the share of adults with at least one grade of improvement in submental fat after deoxycholate or phosphatidylcholine injections versus placebo, in four randomised trials.
TrialImproved by at least one grade (dark = treated, grey = placebo)
REFINE-1, USA and Canada, 506 adults
Treated: 70.0%
Placebo: 18.6%
REFINE-2, USA and Canada, 516 adults
Treated: 66.5%
Placebo: 22.2%
MEI005 trial, China, 325 adults
Treated: 68.9%
Placebo: 21.6%
AYP-101 trial (phosphatidylcholine), Korea, 96 adults
Lower dose: 69.7%
Placebo: 22.6%

Sources: PubMed records 26673433, 27430612, 40037621 and 40850886. Each trial used two rating scales and judged results 4 to 12 weeks after the last session. None of the four tested Aqualyx. Compiled by BeauLife Clinic.

One grade on these scales is a visible but moderate change. Bigger changes were less common: in REFINE-2, 18.6% of treated adults improved by two grades, against 3.0% on placebo. Three details help set expectations:

  • Session count matters. The trials allowed up to six sessions; most patients improve gradually rather than after the first one.
  • Asian data now exist. In the Chinese trial, MRI showed at least a 10% fat volume drop in 50% of treated adults, against 15.2% on placebo.
  • Aqualyx evidence is smaller. The main Aqualyx paper is a four-year Italian series of 186 patients, which focused on safety rather than measured fat loss.
Key takeaway: Expect a moderate, gradual change for most people, not a dramatic one. The ingredient has strong trial support; the exact product and dose still matter.

5. How long does the swelling last after the injection?

Quick Answer: Swelling usually peaks over the first two or three days and settles within about three to five days, according to a 186-patient Aqualyx series. Bruising, tenderness and numbness are common. In Kybella trials, nine in ten treated patients had swelling. Plan sessions away from big events, and check your aesthetic clinic in Malaysia is MOH-registered before booking.

Side effects after deoxycholic acid injection under the chin vs placebo (pooled trials)
Grouped bars of injection-site and other side effects in 513 adults treated with deoxycholic acid versus 506 on placebo in the two pooled US phase 3 trials.
Side effectShare of patients (dark = treated, n=513; grey = placebo, n=506)
Swelling
87%
43%
Bruising
72%
70%
Pain at the site
70%
32%
Numbness
66%
6%
Firmness (induration)
23%
3%
Small lumps (nodules)
13%
3%
Temporary jaw-nerve weakness
4%
under 1%
Trouble swallowing
2%
under 1%

Source: Kybella US prescribing information, 2015, Table 1 (FDA). Placebo injections also cause bruising and pain, which is why the gap matters more than the raw figure. Compiled by BeauLife Clinic.

A typical course of recovery after one session looks like this:

  • Day 0. Burning for a few minutes, then warmth and tightness.
  • Days 1–3. Swelling and tenderness peak; the chin can look fuller than before.
  • Days 3–7. Swelling eases. Itching may start, reported by 21.5% in the Aqualyx series.
  • Weeks 2–8. Numbness or firmness can linger. The label notes numbness lasting over 30 days in 42% of treated patients.

Serious problems are rare but real. A 2024 review of US safety reports found skin necrosis, nerve weakness and swallowing trouble among the reported events, and Malaysia’s NPRA and Medical Device Authority regulate what may be used here.

Key takeaway: Book two to three quiet days after each double chin fat melting injection session. Numbness can last weeks, and any trouble swallowing or a lopsided smile should be reported to the doctor straight away.

6. Are the results of chin fat injections long-lasting?

Quick Answer: Yes for most people. In a follow-up of the REFINE trials, 82.4% of treated adults who had improved still held that improvement three years later. Fat cells broken down by a double chin fat melting injection do not grow back, but the remaining ones can still enlarge with weight gain. Our Aqualyx guide covers aftercare.

Share of earlier responders who kept their chin improvement, years 1 to 3
Time-series of the share of REFINE responders who maintained at least one grade of submental fat improvement at years 1, 2 and 3 after deoxycholic acid versus placebo, with satisfaction at year 3.
Time after last sessionKept at least one grade of improvement
Year 1
86.4% treated (vs 56.8% placebo)
Year 2
90.6% treated (vs 73.8% placebo)
Year 3
82.4% treated (vs 65.0% placebo)
Still satisfied at year 3
74% of those satisfied at week 12

Source: Humphrey et al. 2021, Aesthetic Surgery Journal (PMID 33617632); 224 earlier responders (113 treated, 111 placebo). Placebo responders were people who had improved without the drug, which is why their figures are not zero.

The three-year follow-up study enrolled only people who had already improved, so it shows durability, not the chance of improving in the first place. No new treatment-related side effects appeared during the follow-up.

For larger bulges elsewhere, the same logic applies. Our guide to tummy fat removal without surgery explains why injections suit small pockets and freezing suits bigger ones.

Key takeaway: Once the fat cells are gone, the shape usually holds for years. Weight gain is the main thing that can undo it.

Planning a course around work or an event?

Tell us your dates and a BeauLife doctor will space the sessions so the swelling falls on quieter days.

Compare with CoolSculpting for larger areas

7. How much does a double chin fat melting injection cost in Malaysia?

Quick Answer: In the Klang Valley, an Aqualyx double chin fat melting injection typically starts from about RM 699 per session. A course of two sessions starts from about RM 1,400 and three from about RM 2,100. Larger or fuller chins need more vials, so the exact quote follows a consultation. Cooltech Define starts from about RM 800 per cycle.

PlanTypical Klang Valley priceNote
Aqualyx, one sessionFrom about RM 699Depends on area size and vials used
Aqualyx, two sessionsFrom about RM 1,400Illustrative: two sessions at the starting price
Aqualyx, three sessionsFrom about RM 2,100Illustrative: three sessions at the starting price
For context: Cooltech Define, one cycleFrom about RM 800A wide chin may take two cycles
For context: CoolSculpting, one areaRM 1,500 – 2,500No needles

Before you compare prices, ask three questions:

  • How many vials or millilitres per session? A low per-session price can mean less product.
  • How many sessions are planned? Compare the whole course, not one visit.
  • Can I see the box and QR code? Counterfeit fat-dissolving products are on the market.
Key takeaway: Budget for two to three sessions. A low price for one session does not always mean a low price for the course.

8. The short version

A double chin fat melting injection breaks down fat cells with a bile-acid compound, and the body clears them over the following weeks. It suits a small, soft pocket of fat in someone with a stable weight. Expect a few swollen days after each of two to three sessions, a moderate change that builds gradually, and results that usually hold. The doctor’s skill matters most: correct depth and a clear line below the jaw.

9. Frequently Asked Questions

1. How many sessions of double chin fat melting injection do I need?

Most people need two to three Aqualyx sessions, four to six weeks apart. Kybella trials allowed up to six sessions at least a month apart. The doctor judges progress about eight to twelve weeks after the last one.

2. Is a double chin fat melting injection painful?

The solution burns for a few minutes after injection. Ice or a local numbing agent can make it more comfortable. Tenderness and numbness are common for days to weeks afterwards.

3. When will I see results from chin fat injections?

Swelling hides the change for the first week. Most people see a clearer difference after the second session, and the final result is judged two to three months after the last one.

4. Can fat melting injections cause a crooked smile?

Rarely. In pooled US trials, 4% of treated patients had temporary weakness of the nerve that moves the lower lip, and most cases resolved. Keeping injections away from the strip below the jawbone lowers the risk.

5. Are Aqualyx and Kybella the same?

Both are deoxycholate-based, but they are different products. Kybella is US-approved for fat under the chin and is not widely offered in Malaysia. Aqualyx is an Italian product with smaller published studies.

6. How much does a double chin fat melting injection cost in Malaysia?

In the Klang Valley, Aqualyx typically starts from about RM 699 per session, or from about RM 1,400 to 2,100 for a course of two to three sessions. The exact quote is given after a consultation.

Ready to find out if injections suit your chin?

WhatsApp us on +6016-251 7687. A BeauLife doctor will check whether the fullness is fat, explain the safe zone and the likely number of sessions, and give you a quote for the whole course. We open 10am–7pm on weekdays and 10am–5pm on weekends at Bukit Jalil, Cheras, Puchong, Subang Jaya and Ampang.

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Double Chin Fat Melting InjectionBotox & Body

BeauLife Medical Team

Our articles are written and reviewed by the doctors at BeauLife Clinic, a doctor-led, non-surgical aesthetic clinic with five branches across the Klang Valley since 2017.

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A double chin fat melting injection uses deoxycholate, a bile-acid compound, to break down the walls of fat cells under the chin. The body then clears the fat over several weeks. Most people need two to three sessions, four to six weeks apart, and swelling for a few days after each. In the Klang Valley, Aqualyx typically starts from about RM 699 per session, with the exact quote after a consultation.
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