Profhilo vs Rejuran: Which Skin Booster Suits You?

If you are weighing up Profhilo vs Rejuran, you have probably read that one “hydrates” and the other “repairs”, and that many clinics combine them. That is broadly true, but it does not tell you which one to book first, what each feels like, how strong the proof is or what a full year costs.

This guide answers those four questions with published studies and Klang Valley price ranges. It is written by BeauLife Clinic, an MOH-registered aesthetic clinic (KKLIU 1970/2019) operating since 2017, with LCP-certified doctors at five Klang Valley branches. It does not replace a doctor’s assessment of your skin.

First, this short video from a US dermatologist explains what “salmon DNA” boosters such as Rejuran are, and what the evidence does and does not show.

1. What is the difference between Profhilo and Rejuran?

Quick Answer: Profhilo and Rejuran are both injectable skin boosters, but they are made of different things. Profhilo is 64 mg of hyaluronic acid in 2 ml, which holds water and supports firmness. Rejuran is polynucleotides, purified salmon DNA fragments, thought to support skin repair. Neither adds volume like a filler. Our Profhilo treatment page covers the HA side in detail.

Think of it as water versus building blocks. HA draws water into the skin and spreads under it, so skin feels plumper and springier. PN is believed to calm inflammation and give skin cells raw material for repair, so the change shows up as smoother texture and calmer skin. Our Rejuran skin booster page lists what each Rejuran version is for.

2. Profhilo vs Rejuran: how strong is the evidence for each?

Quick Answer: Both have small evidence bases. A 2026 review of Profhilo pooled nine studies and 278 people, and a 2025 review of polynucleotides pooled nine studies and 219 people, rated low to moderate quality. Profhilo has more safety data; PN has more trials in Asian skin. The chart compares them.

Two cautions apply to both. Most studies are small and short, often three to six months. Several Profhilo papers have IBSA employees as authors, and some PN studies were run by advisers to the Rejuran maker. The one independent placebo-controlled Profhilo trial found that 54.5% of patients were unsatisfied with the result, a useful check on expectations.

One local note: a BeauLife Clinic doctor was among the investigators in a 2025 neck-laxity survey of patients from Malaysia, Singapore and Indonesia. The average laxity grade fell from 3.08 to 2.12 by day 90.

3. Which is better for dry skin, pores, acne scars or redness?

Quick Answer: Choose Profhilo for dehydrated, crepey or slightly loose skin on the face, neck or hands. Choose Rejuran for rough texture, pores, shallow acne scars, redness and skin recovering from laser or RF. For fine lines, both can help. If acne-prone skin is your worry, our guide to skin boosters for oily, acne-prone skin goes further.

Most faces have more than one concern. Dry skin with large pores, or loose skin with redness, is common in Malaysia’s heat and humidity. That is why the doctor ranks your concerns before choosing, and why a plan sometimes uses both boosters. For pigment rather than texture, neither booster is the main tool; see our guide to the benefits of pico laser.

4. Has anyone compared Profhilo and Rejuran directly?

Quick Answer: Not as brands. We found no published trial putting Profhilo and Rejuran on the same patients. The closest is a Korean split-face trial of 27 people comparing a PN booster with a non-cross-linked HA booster around the eyes. Overall scores were similar, but PN did better on roughness, pores and elasticity.

What the head-to-head evidence does and does not tell you:

• It is not Profhilo. The HA used in that trial was a different product, so treat it as “PN vs HA”, not “Rejuran vs Profhilo”.
• It is the eye area only. The 2026 eye-area review found one more trial with PN ahead of HA, but none followed patients past six months.
• It favours repair measures. PN won on texture, which is what you would expect from a repair booster. HA’s strength, hydration and springiness across the cheeks, was not the main test.

So the honest answer to “which is stronger?” is that they have not been tested against each other in the way that would settle it. Choosing by concern is more reliable than choosing by reputation.

5. Does Profhilo or Rejuran hurt more, and which has more downtime?

Quick Answer: Rejuran usually stings more, because it means many small injections of a thicker gel. In one trial, a standard PN booster scored about 5 out of 10 for pain. Profhilo uses only ten injection points, and patients in the neck survey reported low to moderate pain. Both leave small bumps that usually settle within one to two days.

Plan around events. Profhilo’s ten bumps are easy to cover after a day. Rejuran’s grid of bumps can take a little longer, so book either booster at least a week before a wedding, photo shoot or festive gathering. Numbing cream is used for both.

6. Can you combine Profhilo and Rejuran?

Quick Answer: Yes. Many doctors use both, because hydration and repair are separate problems. Common plans alternate the two a few weeks apart, or give Rejuran after a device such as Sylfirm X to help the skin recover. In a survey of 235 Korean dermatologists, 79% of those using PN combined it with lasers or devices.

Three combination patterns you may be offered:

• Alternating boosters. Profhilo for hydration in one visit, Rejuran for texture a few weeks later. This suits dry skin with large pores.
• Device then booster. Needle RF or laser first, Rejuran straight after. In a 25-patient split-face trial, the Rejuran side recovered from redness faster than the saline side.
• A PN-HA mix. Rejuran HB blends PN with non-cross-linked HA for repair plus some hydration in one product.

Other boosters may fit the same slot. Plenhyage is another PN option, and Restylane skin boosters are an HA option for fine lines. Our guide to Rejuran skin booster types, cost and sessions in Malaysia covers the Rejuran versions in depth.

7. How much do Profhilo and Rejuran cost in a first year?

Quick Answer: In the Klang Valley, Profhilo typically costs RM 2,000 to 4,500 per 2 ml session and Rejuran RM 1,200 to 2,500 per session. Because Profhilo needs two starter sessions and Rejuran about three, a first year with one maintenance visit is roughly RM 6,000 to 13,500 for Profhilo and RM 4,800 to 10,000 for Rejuran.

Per session, Rejuran usually looks cheaper. Over a year the gap narrows, because it needs more visits. When you compare quotes, ask:

• How many syringes or ml per session, and whether the neck is included.
• Which Rejuran version is planned; Rejuran S and eye treatments may be quoted differently.
• Whether you can see the sealed box and batch label before the injection.

8. Should I get Profhilo or Rejuran first?

Quick Answer: Start with the booster that matches your biggest concern. If your skin is dry and starting to soften, Profhilo usually comes first. If texture, pores, redness or scars bother you most, start with Rejuran. If you are planning laser or RF, Rejuran is often timed straight after it.

A simple way to decide before your consultation:

1. Name your main concern. Write down the one thing you most want to change: dryness, softening, pores, texture, redness or scars.
2. Check your calendar. Allow at least a week before any event, and note planned laser or RF sessions.
3. Mention allergies and health. Tell the doctor about fish allergy, pregnancy, breastfeeding, skin infections and medicines.
4. Agree the whole course. Confirm the number of sessions, spacing, maintenance and total before the first injection.

If you are seeing a clinic for the first time, our guide on how to choose a safe aesthetic clinic in Malaysia explains the registration and doctor checks to make.

9. When is neither Profhilo nor Rejuran the right choice?

Quick Answer: Neither booster lifts sagging skin, fills deep folds or restores lost cheek volume. For visible sagging, an energy device such as Thermage FLX works on a deeper layer. For hollows and volume loss, collagen stimulators may suit better; our Sculptra vs Ellansé guide compares two of them.

• Deep folds and jowls. These are structural, so a booster alone will disappoint.
• Pregnancy or breastfeeding. Both are usually postponed.
• Active acne, infection or cold sores in the area. Treat these first.
• Fish or salmon allergy. Rejuran is usually avoided; Profhilo may be considered instead.

10. The short version

Profhilo vs Rejuran is not a contest with one winner. Profhilo is the hydration-and-early-laxity booster with fewer injections and fewer sessions. Rejuran is the repair booster for texture, pores, redness, scars and recovery after devices. The evidence for both is real but modest, and no trial has pitted the brands against each other. Choose by your main concern, plan by the year rather than the session, and let a doctor confirm the fit.

11. Frequently Asked Questions